jQuery File Upload is an awesome jQuery plugin for creating a flexible and user-friendly upload functionality with ease.
The plugin support multiple file selection and drag & drops. It can display a preview of images to be uploaded and progress bars exist to inform users.
Plugin works with any server-side platform (Google App Engine, PHP, Python, Ruby on Rails, Java, etc.) that supports standard HTML form file uploads.

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jQuery File Upload can handle cross-domain, chunked and resumable file uploads. File types and max-min sizes can be restricted with simple functions and it can work with any server-side language.
There are callbacks on every level and a detailed documentation that covers many different scenarios exists.
Requirements: jQuery
Website: http://blueimp.github.com/jQuery-File-Upload/